An international team of researchers has struck an important blow in the ongoing evolutionary arms race with the notorious potato disease late blight (Phytophthora infestans). This disease, which caused the Irish potato famine in the 1840s, continues to reduce potato yields today and can lead to devastating losses.
A new gene and it’s relatives were found in the Solanum americanum plant and seem to provide potatoes resistance against all races of P. infestans . A publication on the new Rpi-amr1-gene appears today in Nature Plants.
Resistance genes in plants provide protection by allowing the plant to perceive pathogenic microorganisms and upon perception, activate defence against them. However, single resistance genes often act against a limited range of pathogen races and can be overcome by new variants. The challenge is to find new resistance genes that provide protection against the widest range of pathogens and their variants, buying time in an ongoing evolutionary arms race.
To address this challenge, researchers from The Sainsbury Lab in UK, Wageningen University & Research (WUR) and their co-workers from other institutions explored the diversity of resistance genes in a wide range of wild Solanum plants related to potato. They found Solanum americanum, the ancestor of the widespread wild plant Solanum nigrum (black nightshade) to be an excellent source of new resistance genes against late blight.
In their study, they report resistance gene Rpi-amr1 and its many variants. Despite varying in sequence by up to 10%, each Rpi-amr1 variant enables the plant to detect the same effector proteins of late blight, affording protection from disease.
Late blight strains carry two related effector proteins that are both recognized by most of the Rpi-amr1 variants. This is important because pathogens overcome resistance by losing or substantially modifying their effector proteins through evolution. The chances of losing or modifying several effector proteins at the same time is lower. Rpi-amr1 confers resistance against all of the 19 blight strains tested.
The Rpi-amr1 resistance gene is being combined with two other resistance genes, Rpi-amr3 and Rpi-vnt1, in the commercial potato Maris Piper. The resulting potato lines are immune to a very wide diversity of blight races. This work would not have been possible without the added value that collaboration creates.
Professor Vivianne Vleeshouwers from WUR worked closely with Professor Jonathan Jones and Sophien Kamoun from The Sainsbury Laboratory in Norwich (UK) and others from the John Innes Centre, the Technical University of Munich, and the Universities of East Anglia, Leeds and Hull.
The research paper on this work was published today in the journal Nature Plants, titled ‘A complex resistance locus in Solanum americanum recognizes a conserved Phytophthora effector‘, Nature Plants. 11 February 2021. DOI: 10.1038/s41477-021-00854-9.
For more information, please contact Professor Vivianne Vleeshouwers ([email protected]; +31 317 487460).
Source: Wageningen University & Research (WUR)
Cover photo: Field trial with wild Solanum americanum plant. In the background diseased potatoes, affected by Phytophthora.